Chemical formula: C₂₅H₃₂ClFO₅ Molecular mass: 410.907 g/mol PubChem compound: 5311051
Clobetasol propionate, like other topical corticosteroids, has anti-inflammatory, antipruritic, and vasoconstrictive properties. Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D07AD01 | Clobetasol | D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07A Corticosteroids, plain → D07AD Corticosteroids, very potent (group IV) |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| DERMOVATE Scalp application | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| CLARELUX Cutaneous foam | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Clobetasol propionate is an active ingredient of these brands:
United States (US)Australia (AU)
Austria (AT)Brazil (BR)Cyprus (CY)
Ecuador (EC)Estonia (EE)
Finland (FI)
France (FR)Germany (DE)
Hong Kong (HK)
Israel (IL)
Italy (IT)Japan (JP)Lithuania (LT)
Mexico (MX)
Netherlands (NL)New Zealand (NZ)
Nigeria (NG)
Poland (PL)Singapore (SG)
South Africa (ZA)Spain (ES)Tunisia (TN)
Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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