UPERIO

This brand name is authorized in Nigeria.

Active ingredients

The drug UPERIO contains a combination of these active pharmaceutical ingredients (APIs):

1	Sacubitril UNII 17ERJ0MKGI - SACUBITRIL
	Sacubitril is a prodrug and its active metabolite, LBQ657, inhibits neprilysin (neutral endopeptidase; NEP). The complementary cardiovascular benefits in heart failure patients are attributed to the enhancement of peptides that are degraded by neprilysin, such as natriuretic peptides (NP), by LBQ657.
	Read more about Sacubitril
2	Valsartan UNII 80M03YXJ7I - VALSARTAN
	Valsartan is an orally active, potent, and specific angiotensin II (Ang II) receptor antagonist. It acts selectively on the AT1-receptor subtype, which is responsible for the known actions of angiotensin II.
	Read more about Valsartan

Packages

This drug has been approved in Nigeria as follows:

Identifier	Form	Presentation	Description	Approval
B4-7237	Tablet	Uperio 100mg Tablet TAB 49 mg; 51 mg 28	95 RNW-PP-270300 Uperio 100mg Tablet VALSARTAN + SACUBITRIL Sacubitril 49mg, Valsartan 51mg, Excipients: Microcrystalline cellulose, low-substituted hydroxypropylcellulose, crospovidone, magnesium stearate (vegetable origin), talc and colloidal silicon dioxide, hypromellose, titanium dioxide (E 171), Macrogol 4000, talc, iron oxide red (E 172), iron oxide black (E 172). B4-7237 Drugs Imported Products 28 POM 2 6/24/2022 NOVARTIS NIGERIA LIMITED, LANDMARK BUILDING 52/54 ISAAC JOHN STREET IKEJA-GRA LAGOS LAGOS 2.34707E+12 arit.onwusah@novartis.com Novartis Farma S.P.A, Novartis Farma S.P.A Torre Annunziata, Italy, Italy	06/07/2023
B4-7238	Tablet	Uperio 200mg Tablet TAB 200 mg 7 x 4, 6 x 10	Uperio 200mg Tablet SACUBITRIL + VALSARTAN Sacubitril 97.2mg, Valsartan 102.8mg Excipients: Microcrystalline cellulose, low-substituted hydroxypropylcellulose, crospovidone, magnesium stearate (vegetable origin), talc and colloidal silicon dioxide, hypromellose, titanium dioxide (E 171), Macrogol 4000, talc, iron oxide red (E 172) and iron oxide black (E 172). B4-7238 Drugs Imported Products 74,610 POM 1 7/8/2022 NOVARTIS NIGERIA LIMITED, LANDMARK BUILDING 52/54 ISAAC JOHN STREET IKEJA-GRA LAGOS LAGOS 2.34707E+12 arit.onwusah@novartis.com Novartis Farma S.P.A, Novartis Farma S.P.A Torre Annunziata, Italy, Italy 3.90815E+11 nicolas.chornet@novartis.com	27/07/2023
B4-7690	Tablet	Uperio 50mg Tablet TAB 24 mg; 26 mg 2X14	78 RNW-PP-273738 Uperio 50mg Tablet SACUBITRIL + VALSARTAN Sacubitril: 24.3mg, Valsartan, 25.7mg Excipients: Microcrystalline cellulose, low-substituted hydroxypropylcellulose, crospovidone, magnesium stearate (vegetable origin), talc and colloidal silicon dioxide, hypromellose, titanium dioxide (E 171), Macrogol 4000, talc, iron oxide red (E 172), iron oxide black (E 172). B4-7690 Drugs Imported Products 214 POM 1 7/21/2022 NOVARTIS NIGERIA LIMITED, LANDMARK BUILDING 52/54 ISAAC JOHN STREET IKEJA-GRA LAGOS LAGOS 2.34707E+12 arit.onwusah@novartis.com Novartis Farma S.P.A, Novartis Farma S.P.A Torre Annunziata, Italy, Italy	27/07/2023

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
C09DX04	Valsartan and sacubitril	C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09D Angiotensin II antagonists, combinations → C09DX Angiotensin II antagonists, other combinations
Discover more medicines within C09DX04

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
NG	Registered Drug Product Database	B4-7237, B4-7238, B4-7690