Acalabrutinib

Chemical formula: C₂₆H₂₃N₇O₂  Molecular mass: 465.517 g/mol  PubChem compound: 71226662

Therapeutic indications

Acalabrutinib is indicated for:

Mantle cell lymphoma

Population group: only adults (18 years old or older)

Acalabrutinib is indicated for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Chronic lymphocytic leukaemia

Population group: only adults (18 years old or older)

Acalabrutinib as monotherapy or in combination with obinutuzumab is indicated for the treatment of adult patients with previously untreated chronic lymphocytic leukaemia (CLL).

Acalabrutinib as monotherapy is indicated for the treatment of adult patients with chronic lymphocytic leukaemia (CLL) who have received at least one prior therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Small lymphocytic lymphoma

Population group: only adults (18 years old or older)

Acalabrutinib is indicated for the treatment of adult patients with small lymphocytic lymphoma (SLL).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Acalabrutinib is contraindicated in the following cases:

Lactation

Lactation

Strong CYP3A/P-gp inhibitors

at least one of
Strong CYP3A4 inhibitors
Cytochrome P-450 CYP3A5 strong inhibitors
and additionally P-glycoprotein inhibitors

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