Chemical formula: C₂₀H₂₆N₂O₂ Molecular mass: 326.433 g/mol PubChem compound: 6100671
Ajmaline is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. It produces potent sodium channel blocking effects and a very short half-life which makes it a very useful drug for acute intravenous treatments. The drug has been very popular in some countries for the treatment of atrial fibrillation in patients with the Wolff–Parkinson–White syndrome and in well tolerated monomorphic ventricular tachycardias. It has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope. In these cases, abnormal prolongation of the HV interval has been taken as a proof for infrahisian conduction defects tributary for permanent pacemaker implantation.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C01BA05 | Ajmaline | C Cardiovascular system → C01 Cardiac therapy → C01B Antiarrhythmics, class I and III → C01BA Antiarrhythmics, class Ia |
Ajmaline is an active ingredient of these brands:
Austria (AT)Malta (MT)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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