Alemtuzumab

Chemical formula: C₆₄₆₈H₁₀₀₆₆N₁₇₃₂O₂₀₀₅S₄₀  Molecular mass: 145,453.8 g/mol 

Therapeutic indications

Alemtuzumab is indicated for:

Relapsing remitting multiple sclerosis (RRMS)

Population group: only adults (18 years old or older)

Alemtuzumab is indicated as a single disease modifying therapy in adults with highly active relapsing remitting multiple sclerosis (RRMS) for the following patient groups:

  • Patients with highly active disease despite a full and adequate course of treatment with at least one disease modifying therapy (DMT) or
  • Patients with rapidly evolving severe relapsing remitting multiple sclerosis defined by 2 or more disabling relapses in one year, and with 1 or more Gadolinium enhancing lesions on brain MRI or a significant increase in T2 lesion load as compared to a previous recent MRI.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Alemtuzumab is contraindicated in the following cases:

Human Immunodeficiency Virus (HIV) infection

Human immunodeficiency virus infection

Pregnancy

Pregnancy

Severe active infection

Infectious disease

Lactation

Lactation

Hypertension

Hypertension

Arterial dissection of the cervicocephalic arteries

Dissection of cervicocerebral artery

Stroke

at least one of
CVA - Cerebrovascular accident
H/O: CVA

Angina pectoris, myocardial infarction

at least one of
H/O: angina pectoris
Angina
Myocardial infarction
Past history of myocardial infarction

Coagulopathy, anti-platelets, anti-coagulants

at least one of
Blood coagulation disorder
Antithrombotic agents

Concomitant autoimmune diseases

Autoimmune disease and additionally not Relapsing remitting multiple sclerosis

Get recommendations

Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

Ask the Reasoner

Related medicines

Summary of Product Characteristics (SPC) 2020: LEMTRADA Concentrate for solution for infusion
< Previous: Overview
Next: Precautions >

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.

⇈