Alfacalcidol Other names: 1alpha-hydroxyvitamin D3 Alphacalcidol 1-hydroxycholecalciferol 1alpha-hydroxycholecalciferol

Chemical formula: C₂₇H₄₄O₂  Molecular mass: 400.637 g/mol  PubChem compound: 5282181

Active ingredient description

Alfacalcidol is Vitamin D-hormone analog (an active metabolite of Vitamin D), which performs important functions in regulation of the calcium balance and the bone metabolism and is activated by the enzyme 25-hydroxylase (converted rapidly in the liver to 1,25-dihydroxyvitamin D) for systemic and in osteoblasts for local D-hormone actions.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A11CC03 Alfacalcidol A Alimentary tract and metabolism → A11 Vitamins → A11C Vitamin A and D, incl. combinations of the two → A11CC Vitamin D and analogues
Discover more medicines within A11CC03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ONE-ALPHA Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ONE-ALPHA Capsules Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 41294-56-8
DrugBank Drug: DB01436
KEGG Drug: D01518
PubChem Compound: 5282181
RxNorm Ingredient: 12062
SNOMED-CT Concept: 11984007
Alfacalcidol (substance)
UNII Identifier: URQ2517572
ALFACALCIDOL

Medicines

Alfacalcidol is an active ingredient of these brands:

Austria (AT)

Brazil (BR)

Canada (CA)

Cyprus (CY)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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