Aliskiren and Hydrochlorothiazide

Therapeutic indications

Aliskiren and Hydrochlorothiazide is indicated for:

Essential hypertension

Population group: only adults (18 years old or older)

Treatment of essential hypertension in adults.

Aliskiren/hydrochlorothiazide combination is indicated in patients whose blood pressure is not adequately controlled on aliskiren or hydrochlorothiazide used alone.

Aliskiren/hydrochlorothiazide combination is indicated as substitution therapy in patients adequately controlled with aliskiren and hydrochlorothiazide, given concurrently, at the same dose level as in the combination.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

150 mg/12.5 mg, 150 mg/25 mg, 300 mg/12.5 mg or 300 mg/25 mg of aliskiren/hydrochlorothiazide once daily

Contraindications

Aliskiren and Hydrochlorothiazide is contraindicated in the following cases:

Pregnancy

Severe hepatic impairment

Hepatic failure stage IV

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Hyponatraemia, hypercalcaemia, symptomatic hyperuricaemia and refractory hypokalaemia

at least one of

Hyponatremia
Hypercalcemia
Hyperuricemia
Hypokalemia

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