Amikacin

Chemical formula: C₂₂H₄₃N₅O₁₃  Molecular mass: 585.603 g/mol  PubChem compound: 37768

Therapeutic indications

Amikacin is indicated for:

Bacterial infectious disease

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Amikacin is an aminoglycoside antibiotic which is active against a broad spectrum of Gram-negative organisms, including Pseudomonas spp, Escherichia coli, indole-positive and indole-negative Proteus spp. Klebsiella-Enterobacter-Serratia spp, Salmonella, Shigella, Minea-Herellae, Citrobacter freundii and Providencia spp.

Many strains of these gram-negative organisms resistant to gentamicin and tobramycin may show sensitivity to amikacin in vitro. The principal Gram-positive organism sensitive to amikacin is Staphylococcus aureus, including methicillin-resistant strains. Amikacin has some activity against other Gram-positive organisms including certain strains of Streptococcus pyogenes, Enterococci and Diplococcus pneumoniae.

Amikin is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. It may also be indicated for the treatment of known or suspected staphylococcal disease.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Bacterial infectious disease

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old)

Amikacin is an aminoglycoside antibiotic which is active against a broad spectrum of Gram-negative organisms, including Pseudomonas spp, Escherichia coli, indole-positive and indole-negative Proteus spp. Klebsiella-Enterobacter-Serratia spp, Salmonella, Shigella, Minea-Herellae, Citrobacter freundii and Providencia spp.

Many strains of these gram-negative organisms resistant to gentamicin and tobramycin may show sensitivity to amikacin in vitro. The principal Gram-positive organism sensitive to amikacin is Staphylococcus aureus, including methicillin-resistant strains. Amikacin has some activity against other Gram-positive organisms including certain strains of Streptococcus pyogenes, Enterococci and Diplococcus pneumoniae.

Amikin is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. It may also be indicated for the treatment of known or suspected staphylococcal disease.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Bacterial infectious disease

Population group: only newborns (0 - 40 days old)

Amikacin is an aminoglycoside antibiotic which is active against a broad spectrum of Gram-negative organisms, including Pseudomonas spp, Escherichia coli, indole-positive and indole-negative Proteus spp. Klebsiella-Enterobacter-Serratia spp, Salmonella, Shigella, Minea-Herellae, Citrobacter freundii and Providencia spp.

Many strains of these gram-negative organisms resistant to gentamicin and tobramycin may show sensitivity to amikacin in vitro. The principal Gram-positive organism sensitive to amikacin is Staphylococcus aureus, including methicillin-resistant strains. Amikacin has some activity against other Gram-positive organisms including certain strains of Streptococcus pyogenes, Enterococci and Diplococcus pneumoniae.

Amikin is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. It may also be indicated for the treatment of known or suspected staphylococcal disease.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Peritonitis

Population group: only minors (0 - 18 years old) , adults (18 years old or older)

Peritonitis and additionally Amikacin susceptible species

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Amikacin is contraindicated in the following cases:

Pregnancy

Pregnancy

Anaesthetics, muscle-relaxing drugs

at least one of
Anesthetics
Diethyl ether
Halothane
Tubocurarine
Suxamethonium
DECAMETHONIUM
Atracurium besilate
Rocuronium
Vecuronium

Neurotoxic, ototoxic or nephrotoxic agents

at least one of
Bacitracin
Cis-Diaminedichloroplatinum
Carboplatin
Oxaliplatin
Amphotericin B
Ciclosporin
Tacrolimus
Cefaloridine
Paromomycin
VIOMYCIN
Polymyxin B
Colistin
Vancomycin

Myasthenia gravis

Myasthenia gravis

Hypersensitivity to aminoglycosides

Aminoglycoside allergy

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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