Chemical formula: C₂₁H₃₅NO Molecular mass: 317.517 g/mol PubChem compound: 54260
Amorolfine is a topical antimycotic. Amorolfine belongs to a new chemical class, and its fungicidal action is based on an alteration of the fungal cell membrane targeted primarily on sterol biosynthesis. The ergosterol content is reduced, and at the same time unusual sterically nonplanar sterols accumulate.
Amorolfine is a broad spectrum antimycotic. It is highly active (MIC <2mcg/ml) in vitro against:
yeasts: Candida, Cryptococcus, Malassezia
dermatophytes: Trichophyton, Microsporum, Epidermophyton
moulds: Hendersonula, Alternaria, Scopulariopsis
dematiacea: Cladosporium, Fonsecaea, Wangiella
dimorphic fungi: Coccidioides, Histoplasma, Sporothrix
With the exception of Actinomyces, bacteria are not sensitive to amorolfine.
Propionibacterium acnes is only slightly sensitive.
Amorolfine from nail lacquer penetrates into and diffuses through the nail plate and is thus able to eradicate poorly accessible fungi in the nail bed.
Systemic absorption of the active ingredient is very low with this type of application.
Following prolonged use of amorolfine, there is no indication of drug accumulation in the body.
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