Chemical formula: C₁₆H₁₉N₃O₅S Molecular mass: 365.404 g/mol PubChem compound: 33613
Amoxicillin interacts in the following cases:
Abnormal prolongation of prothrombin time (increased INR) has been reported rarely in patients receiving amoxicillin and oral anticoagulants. Appropriate monitoring should be undertaken when anticoagulants are prescribed concomitantly. Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation.
In common with other antibiotics, amoxicillin may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives.
Tetracyclines and other bacteriostatic drugs may interfere with the bactericidal effects of amoxicillin.
Characteristic rash particularly common in patients with infectious mononucleosis (almost 100%), lymphocytic leukemia (90%) after administration of amoxicillin.
Amoxicillin should be avoided if there is suspicion of infectious mononucleosis because erythematous rashes associated with this condition have been reported following amoxicillin use.
Concurrent administration of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions.
Penicillins may reduce the excretion of methotrexate causing potential increase in toxicity.
Concomitant use of probenecid is not recommended. Probencid decreases the renal tubular secretion of amoxicilin. Concurrent use with amoxicillin may result in increased and prolonged blood levels of amoxicillin.
Amoxicillin may be removed from the circulation by haemodialysis.
500mg every 24h.
Prior to haemodialysis one additional dose of 500mg should be administered. In order to restore circulating blood levels, another dose of 500mg should be administered after haemodialysis.
15 mg/kg/day given as a single daily dose (maximum 500mg).
Prior to haemodialysis one additional dose of 15 mg/kg should be administered. In order to restore circulating blood levels, another dose of 15 mg/kg should be administered after haemodialysis.
The presence of amoxicillin may distort assay results for oestriol in pregnant women.
Amoxicillin maximum 500mg/day.
Population group: only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old)
15 mg/kg given twice daily (maximum 500mg twice daily).
Population group: only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old)
15 mg/kg given as a single dose (maximum 500 mg).
Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Maximum 500mg twice daily.
Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Maximum 500 mg/day.
Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. Limited data on the use of amoxicillin during pregnancy in humans do not indicate an increased risk of congenital malformations. Amoxicillin may be used in pregnancy when the potential benefits outweigh the potential risks associated with treatment.
Amoxicillin is excreted into breast milk in small quantities with the possible risk of sensitisation. Consequently, diarrhoea and fungus infection of the mucous membranes are possible in the breast-fed infant, so that breast-feeding might have to be discontinued. Amoxicillin should only be used during breast-feeding after benefit/risk assessment by the physician in charge.
There are no data on the effects of amoxicillin on fertility in humans. Reproductive studies in animals have shown no effects on fertility.
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