Chemical formula: C₁₀H₁₂ClNO₂ Molecular mass: 213.661 g/mol PubChem compound: 2284
Baclofen is indicated for:
Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Baclofen is indicated for the relief of spasticity of voluntary muscle resulting from such disorders as multiple sclerosis, other spinal lesions e.g. tumours of the spinal cord, syringomyelia, motor neurone disease, transverse myelitis, traumatic partial section of the cord.
Baclofen is also indicated in adults and children for the relief of spasticity of voluntary muscle arising from e.g. cerebrovascular accidents, cerebral palsy, meningitis, traumatic head injury.
Patient selection is important when initiating baclofen therapy; it is likely to be of most benefit in patients whose spasticity constitutes a handicap to activities and/or physiotherapy. Treatment should not be commenced until the spastic state has become stabilized.
Baclofen is indicated in patients 0 to <18 years for the symptomatic treatment of spasticity of cerebral origin, especially where due to infantile cerebral palsy, as well as following cerebrovascular accidents or in the presence of neoplastic or degenerative brain disease.
Baclofen is also indicated for the symptomatic treatment of muscle spasms occurring in spinal cord diseases of infectious, degenerative, traumatic, neoplastic, or unknown origin such as multiple sclerosis, spastic spinal paralysis, amyotrophic lateral sclerosis, syringomyelia, transverse myelitis, traumatic paraplegia or paraparesis, and compression of the spinal cord.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Intrathecal baclofen is indicated in patients with severe chronic spasticity of spinal origin who are unresponsive to oral baclofen or other orally administered antispastic agents and/or those patients who experience unacceptable side-effects at effective oral doses.
In patients with spasticity due to head injury a delay of at least one year before treatment with intrathecal baclofen is recommended, to allow the symptoms of spasticity to stabilise.
Intrathecal baclofen may be considered as an alternative to ablative neurosurgical procedures.
Intrathecal baclofen is indicated in patients aged 4 to <18 years with severe chronic spasticity of spinal origin who are unresponsive to orally administered antispastics (including oral baclofen) and/or who experience unacceptable side effects at effective oral doses.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Intrathecal baclofen is indicated in patients with severe chronic spasticity of cerebral origin who are unresponsive to oral baclofen or other orally administered antispastic agents and/or those patients who experience unacceptable side-effects at effective oral doses.
In patients with spasticity due to head injury a delay of at least one year before treatment with intrathecal baclofen is recommended, to allow the symptoms of spasticity to stabilise.
Intrathecal baclofen may be considered as an alternative to ablative neurosurgical procedures.
Intrathecal baclofen is indicated in patients aged 4 to <18 years with severe chronic spasticity of cerebral origin who are unresponsive to orally administered antispastics (including oral baclofen) and/or who experience unacceptable side effects at effective oral doses.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Baclofen is contraindicated in the following cases:
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