Bazedoxifene

Chemical formula: C₃₀H₃₄N₂O₃ Molecular mass: 470.613 g/mol PubChem compound: 154257

Therapeutic indications

Bazedoxifene is indicated for:

Postmenopausal osteoporosis

Population group: women, only adults (18 years old or older)

Bazedoxifene is indicated for the treatment of postmenopausal osteoporosis in women at increased risk of fracture. A significant reduction in the incidence of vertebral fractures has been demonstrated; efficacy on hip fractures has not been established.

When determining the choice of bazedoxifene or other therapies, including oestrogens, for an individual postmenopausal woman, consideration should be given to menopausal symptoms, effects on uterine and breast tissues, and cardiovascular risks and benefits.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

20 mg once daily

Contraindications

Bazedoxifene is contraindicated in the following cases:

Pregnancy

Lactation

Venous thromboembolic events

at least one of

Pulmonary embolism
Venous embolism
Thromboembolism of vein
History of venous thromboembolic disease

Unexplained uterine bleeding

Abnormal uterine bleeding unrelated to menstrual cycle

Signs or symptoms of endometrial cancer

Primary malignant neoplasm of endometrium

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