Chemical formula: C₂₂H₁₈N₂ Molecular mass: 310.392 g/mol PubChem compound: 2378
There are no clinical data from the use of bifonazole in pregnant women. Studies in animals have shown reproductive toxicity at high oral doses however these effects should not be anticipated at the low systemic exposures observed following topical bifonazole administration.
Bifonazole should only be used during pregnancy after an evaluation by a doctor of the benefit to the patient and the risk to the fetus.
It is unknown whether bifonazole is excreted in human breast milk after topical application.
Bifonazole is excreted in milk after intravenous administration in animals.
A risk to the suckling child cannot be excluded. A decision must be made whether to discontinue breast-feeding or to discontinue bifonazole therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
During the lactation period bifonazole should not be applied to the chest area.
Preclinical studies gave no evidence that bifonazole can impair male or female fertility.
Bifonazole has no or negligible influence on the ability to drive or use machines.
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