Chemical formula: C₁₉H₂₅BN₄O₄ Molecular mass: 384.237 g/mol PubChem compound: 387447
Bortezomib is a proteasome inhibitor. It is specifically designed to inhibit the chymotrypsin-like activity of the 26S proteasome in mammalian cells. Inhibition of the 26S proteasome prevents this targeted proteolysis and affects multiple signalling cascades within the cell, ultimately resulting in cancer cell death.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01XG01 | Bortezomib | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XG Proteasome inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| VELCADE Powder for solution | European Medicines Agency (EU) | MPI, EU: SmPC |
Bortezomib is an active ingredient of these brands:
Australia (AU)Austria (AT)Canada (CA)Croatia (HR)Cyprus (CY)Finland (FI)France (FR)Hong Kong (HK)Ireland (IE)Israel (IL)Japan (JP)Malta (MT)Mexico (MX)Netherlands (NL)New Zealand (NZ)Poland (PL)Spain (ES)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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