Chemical formula: C₂₉H₄₁NO₄ Molecular mass: 467.64 g/mol PubChem compound: 644073
Buprenorphine is an opioid partial agonist/antagonist which attaches itself to the μ (mu) and κ (kappa) receptors of the brain. Its activity in opioid maintenance treatment is attributed to its slowly reversible link with the μ receptors which, over a prolonged period, minimises the need of illicit opioids for patients with opioid dependence.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N02AE01 | Buprenorphine | N Nervous system → N02 Analgesics → N02A Opioids → N02AE Oripavine derivatives |
| N07BC01 | Buprenorphine | N Nervous system → N07 Other nervous system drugs → N07B Drugs used in addictive disorders → N07BC Drugs used in opioid dependence |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| BUTRANS Transdermal system | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| SUBLOCADE Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| BUVIDAL Prolonged-release solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC | |
| BUPRENORPHINE Sublingual tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| RELETRANS Transdermal patch | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| SIXMO Implant | European Medicines Agency (EU) | MPI, EU: SmPC |
Buprenorphine is an active ingredient of these brands:
United States (US)Australia (AU)Austria (AT)
Canada (CA)
Croatia (HR)Cyprus (CY)
Estonia (EE)Finland (FI)France (FR)Germany (DE)
Hong Kong (HK)Ireland (IE)Israel (IL)Italy (IT)
Lithuania (LT)Netherlands (NL)New Zealand (NZ)Poland (PL)Romania (RO)Singapore (SG)South Africa (ZA)Spain (ES)Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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