Burosumab

Therapeutic indications

Burosumab is indicated for:

X-linked hypophosphataemia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Burosumab is indicated for the treatment of X-linked hypophosphataemia, in children and adolescents aged 1 to 17 years with radiographic evidence of bone disease, and in adults.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Tumour-induced osteomalacia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Burosumab is indicated for the treatment of FGF23-related hypophosphataemia in tumour-induced osteomalacia associated with phosphaturic mesenchymal tumours that cannot be curatively resected or localised in children and adolescents aged 1 to 17 years and in adults.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.4 mg/kg once every 2 weeks

0.3 mg/kg once every 2 weeks

0.3 mg/kg once every 4 weeks

Contraindications

Burosumab is contraindicated in the following cases:

Lactation

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)
End stage kidney disease

Phosphate, vitamin D analogues

at least one of

Phosphorus
Phosphoric acid
Vitamin D and analogues
Aluminium phosphate
Calcium phosphate
Magnesium phosphate
Sodium phosphate
Aluminium phosphate
Calcium phosphate
Potassium phosphate
Sodium phosphate

Fasting serum phosphate above the normal range for age

Serum inorganic phosphate above reference range

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