C1 inhibitor is a single chain glycoprotein found in plasma and a member of the serine protease inhibitor, or serpin, superfamily of proteins. C1 inhibitor inhibits the complement system by binding C1r and C1s and is the most important inhibitor of contact activation, regulating the contact system and the intrinsic coagulation pathway by binding to and inactivating kallikrein and factor XIIa.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| B06AC01 | C1-inhibitor, plasma derived | B Blood and blood forming organs → B06 Other hematological agents → B06A Other hematological agents → B06AC Drugs used in hereditary angioedema |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| CINRYZE Powder and solvent for solution for injection | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) |
C1-inhibitor is an active ingredient of these brands:
United States (US)Cyprus (CY)Israel (IL)Japan (JP)Malta (MT)Netherlands (NL)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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