Chemical formula: C₂₇H₄₀O₃ Molecular mass: 412.605 g/mol PubChem compound: 5288783
Calcipotriol interacts in the following cases:
Concomitant administration of calcipotriol and salicylic acid externals may cause an inactivation of calcipotriol.
The safety of the use of calcipotriol during human pregnancy has not been established. Studies in animals have shown reproductive toxicity when calcipotriol was administered orally. Topically applied calcipotriol is slightly systemically absorbed, but a disruption of calcium homeostasis is not expected. As a precautionary measure, it is preferable to avoid the use of calcipotriol in pregnancy.
It is unknown whether calcipotriol is excreted in breast milk.
Short-term use on small surfaces is not expected to lead to a relevant systemic absorption and no effects on the breastfed child are anticipated. In all other cases, breast-feeding is not recommended during treatment with calcipotriol.
There are no data on the effect of calcipotriol therapy on human fertility.
Calcipotriol has no or negligible influence on the ability to drive and use machines.
Based on the clinical data, approximately 25% of the patients treated with calcipotriol could experience an adverse reaction. These reactions are usually mild.
The most frequently reported undesirable effects are various transient skin reactions, in particular lesional/perilesional irritation.
The undesirable effects are listed by MedDra SOC and the individual undesirable effects are listed starting with the most frequently reported.
Very rare (<1/10,000): Hypersensitivity reactions (including urticaria, face or periorbital oedema, angioedema)
Very rare (<1/10,000): Hypercalcaemia, hypercalciuria
Very common: Skin irritation
Common (≥1/100 to <1/10): Pruritus, skin burning sensation, skin stinging sensation, skin dry, erythema, rash (including erythematous, maculo-papular pustular and bullous reactions)
Uncommon (≥1/1,000 to <1/100): Eczema, contact dermatitis, aggravated psoriasis
Very rare (<1/10,000): Transient changes in skin pigmentation, transient photosensitivity, facial and perioral dermatitis
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