Chemical formula: C₁₅H₂₂FN₃O₆ Molecular mass: 359.35 g/mol PubChem compound: 60953
Capecitabine is a non-cytotoxic fluoropyrimidine carbamate, which functions as an orally administered precursor of the cytotoxic moiety 5-fluorouracil (5-FU). There is evidence that the metabolism of 5-FU in the anabolic pathway blocks the methylation reaction of deoxyuridylic acid to thymidylic acid, thereby interfering with the synthesis of deoxyribonucleic acid (DNA). The incorporation of 5-FU also leads to inhibition of RNA and protein synthesis.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01BC06 | Capecitabine | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BC Pyrimidine analogues |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| CAPECITABINE ACCORD Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Capecitabine is an active ingredient of these brands:
United States (US)Australia (AU)Canada (CA)France (FR)Italy (IT)Japan (JP)Malta (MT)Mexico (MX)Netherlands (NL)Poland (PL)Romania (RO)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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