Chemical formula: C₅H₉NO₄S Molecular mass: 179.194 g/mol PubChem compound: 193653
Carbocisteine interacts in the following cases:
In case of impaired renal function or severe hepatopathy, carbocysteine may only be used after medical advice. As with all medicines that are metabolised by the liver and followed by their renal excretion, accumulation of carbocystosine metabolites formed in the liver may occur when severe kidney failure occurs.
Carbocisteine should not be given concomitantly with antitussive drugs or with drugs that have atrophic action.
Carbocysteine may reduce the activity of antimicrobials, such as penicillin, tetracycline or erythromycin.
Animal studies have not shown any teratogenic effects. In the absence of teratogenic effects in animals, malformations are not expected in humans. Currently, substances responsible for malformations in humans were found to be teratogenic in animals during properly carried out studies in two different species.
From a clinical point of view, no malformations or foetotoxicity have occurred.
However, the follow-up of pregnancies in which there is exposition to carbocisteine is not sufficient to exclude all risks.
Consequently, carbocisteine should not be used during pregnancy unless necessary.
There is no data on carbocisteine passing into breast milk.
However, given its low toxicity, the potential risk for children seems negligible if being treated with this medicine. Consequently, breast feeding is possible.
The medicinal product has negligible influence on the ability to drive and use machines.
The evaluation of undesirable effects is based on the following information on frequencies: Very common (≥1/10), Rare (≥1/10,000 to <1/1,000).
There have been reports of anaphylactic reactions and fixed drug eruption.
Very common: stomach pains, nausea, diarrhoea.
There have been reports of gastrointestinal bleeding occurring during treatment with carbocisteine.
Frequency not known: vomiting, gastrointestinal bleeding.
In such cases, it is advised to reduce the dosage.
Rare: itching, rash, erythematous rash, or swelling in the face.
There have been reports of allergic skin eruptions. Isolated cases of bullous dermatitis such as Stevens-Johnson syndrome have also been reported.
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