Cariprazine

Chemical formula: C₂₁H₃₂Cl₂N₄O  Molecular mass: 427.41 g/mol  PubChem compound: 11154555

Active ingredient description

Cariprazine is indicated for the treatment of schizophrenia in adult patients. The mechanism of action of cariprazine is not fully known. However the therapeutic effect of cariprazine may be mediated through a combination of partial agonist activity at dopamine D3, D2 (Ki values of 0.085-0.3 nM versus 0.49-0.71 nM respectively) and serotonin 5-HT1A receptors (Ki values of 1.4-2.6 nM), and antagonist activity at serotonin 5-HT2B, 5-HT2A and histamine H1 receptors (Ki values of 0.58-1.1 nM, 18.8 nM and 23.3 nM, respectively).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N05AX15 N Nervous system → N05 Psycholeptics → N05A Antipsychotics → N05AX Other antipsychotics
Discover more medicines within N05AX15

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
REAGILA Hard capsule European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 839712-12-8
DrugBank Drug: DB06016
KEGG Drug: D09997
PubChem Compound: 11154555
RxNorm Ingredient: 1667655
SNOMED-CT Concept: 715295006
Cariprazine (substance)
UNII Identifier: F6RJL8B278
CARIPRAZINE

Medicines

Cariprazine is an active ingredient of these brands:

United States (US)

Austria (AT)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Croatia (HR)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Cyprus (CY)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Estonia (EE)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Finland (FI)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Ireland (IE)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Israel (IL)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Italy (IT)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Lithuania (LT)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Netherlands (NL)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Poland (PL)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Romania (RO)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Singapore (SG)

  • SYMVENU as CARIPRAZINE HYDROCHLORIDE

South Africa (ZA)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Spain (ES)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Turkey (TR)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

United Kingdom (UK)

  • REAGILA as CARIPRAZINE HYDROCHLORIDE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
Next: Usage >

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.

⇈