Carmustine Other names: Bischlorethylnitrosourea Bischlorethylnitrosurea BCNU
Chemical formula: C₅H₉Cl₂N₃O₂ Molecular mass: 214.05 g/mol PubChem compound: 2578
Active ingredient description
Carmustine is a cell-cycle phase nonspecific antineoplastic agent of the nitrosourea type. As an alkylating agent, it can alkylate reactive sites on nucleoproteins, thus interfering with DNA and RNA synthesis and DNA repair. In addition, carmustine is known to carbamoylate lysine residues on proteins causing irreversible inactivation of enzymes including glutathione reductase.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| L01AD01 | Carmustine | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AD Nitrosoureas |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| CARMUSTINE OBVIUS Powder and solvent for solution for infusion | MPI, EU: SmPC | European Medicines Agency (EU) | |
| GLIADEL Implant | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) |
Medicines
Carmustine is an active ingredient of these brands:
Australia (AU)Austria (AT)Brazil (BR)Canada (CA)Estonia (EE)France (FR)Hong Kong (HK)Ireland (IE)Israel (IL)Japan (JP)New Zealand (NZ)Singapore (SG)South Africa (ZA)Spain (ES)Tunisia (TN)Turkey (TR)United Kingdom (UK)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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