Chloramphenicol

Chemical formula: C₁₁H₁₂Cl₂N₂O₅  Molecular mass: 323.129 g/mol  PubChem compound: 5959

Active ingredient description

Chloramphenicol is a broad spectrum antibiotic which has activity against many types of Gram-positive and Gram-negative bacteria. It acts by interfering with bacterial protein synthesis. Chloramphenicol is widely distributed in body tissues and fluids and enters the cerebrospinal fluid.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D06AX02 Chloramphenicol D Dermatologicals → D06 Antibiotics and chemotherapeutics for dermatological use → D06A Antibiotics for topical use → D06AX Other antibiotics for topical use
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D10AF03 Chloramphenicol D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AF Antiinfectives for treatment of acne
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G01AA05 Chloramphenicol G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AA Antibiotics
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J01BA01 Chloramphenicol J Antiinfectives for systemic use → J01 Antibacterials for systemic use → J01B Amphenicols → J01BA Amphenicols
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S01AA01 Chloramphenicol S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AA Antibiotics
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S02AA01 Chloramphenicol S Sensory organs → S02 Otologicals → S02A Antiinfectives → S02AA Antiinfectives
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S03AA08 Chloramphenicol S Sensory organs → S03 Ophthalmological and otological preparations → S03A Antiinfectives → S03AA Antiinfectives
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Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
Kemicetine Succinate Injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CHLORAMPHENICOL 1.0% Eye ointment Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CLOROGEN Eye drops, solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 56-75-7
CAS Substance: 982-57-0
DrugBank Drug: DB00446
KEGG Drug: D00104
PubChem Compound: 5959
RxNorm Ingredient: 2348
SNOMED-CT Concept: 273949002
Chloramphenicol (substance)
SNOMED-CT Concept: 372777009
Chloramphenicol (substance)
UNII Identifier: 66974FR9Q1
CHLORAMPHENICOL

Medicines

Chloramphenicol is an active ingredient of these brands:

Australia (AU)

Austria (AT)

Brazil (BR)

Cyprus (CY)

Estonia (EE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Mexico (MX)

Nigeria (NG)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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