Chlortalidone Other names: Chlorthalidone

Chemical formula: C₁₄H₁₁ClN₂O₄S Molecular mass: 338.766 g/mol PubChem compound: 2732

Therapeutic indications

Chlortalidone is indicated for:

Stable, chronic heart failure (NYHA: functional class II/III)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

at least one of

Heart failure New York Heart Assosiation Class II
Heart failure New York Heart Assosiation Class IΙΙ

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.5-1.7 mg/kg/48hours

Arterial hypertension

Population group: only adults (18 years old or older)

Treatment of arterial hypertension, essential or nephrogenic or isolated systolic.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

25-50 mg once daily

Stable, chronic heart failure (NYHA: functional class II/III)

Population group: only adults (18 years old or older)

at least one of

Heart failure New York Heart Assosiation Class II
Heart failure New York Heart Assosiation Class IΙΙ

For this indication, competent medicine agencies globally authorize below treatments (click for details):

25-200 mg once daily

Ascites due to cirrhosis, oedema due to nephrotic syndrome

Population group: only adults (18 years old or older)

Oedema of specific origin:

Ascites due to cirrhosis of the liver in stable patients under close control.
Oedema due to nephrotic syndrome.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

25-50 mg once daily

Diabetes insipidus

Population group: only adults (18 years old or older)

Diabetes insipidus

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50-200 mg in 1-2 divided doses daily

Arterial hypertension

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of arterial hypertension, essential or nephrogenic or isolated systolic.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.5-1.7 mg/kg/48hours

Ascites due to cirrhosis, oedema due to nephrotic syndrome

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Oedema of specific origin:

Ascites due to cirrhosis of the liver in stable patients under close control.
Oedema due to nephrotic syndrome.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.5-1.7 mg/kg/48hours

Diabetes insipidus

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Diabetes insipidus

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.5-1.7 mg/kg/48hours

Contraindications

Chlortalidone is contraindicated in the following cases:

Hypersensitivity to chlortalidone

Chlorthalidone allergy

Anuria

Anuria

Severe renal failure (creatinine clearance <30ml/min)

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe hepatic failure

Hepatic failure stage IV

Hypokalaemia

Hypokalemia

Hyponatraemia

Hyponatremia

Hypercalcaemia

Raised serum calcium level

Hyperuricaemia

Hyperuricemia

Addison's disease

Addison's disease

Lithium

Lithium

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