Chemical formula: C₆₂H₁₁₁N₁₁O₁₂ Molecular mass: 1,202.635 g/mol PubChem compound: 5284373
Ciclosporin (also known as ciclosporin A) is a cyclic polypeptide immunomodulator with immunosuppressant properties. It has been shown to prolong survival of allogeneic transplants in animals and significantly improved graft survival in all types of solid organ transplantation in man. Ciclosporin has also been shown to have an anti-inflammatory effect.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L04AD01 | Ciclosporin | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AD Calcineurin inhibitors |
| S01XA18 | Ciclosporin | S Sensory organs → S01 Ophthalmologicals → S01X Other ophthalmologicals → S01XA Other ophthalmologicals |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| NEORAL Oral solution | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| IKERVIS Eye drops, emulsion | European Medicines Agency (EU) | MPI, EU: SmPC | |
| SANDIMMUNE Capsule, Oral solution, Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/Old |
Ciclosporin is an active ingredient of these brands:
United States (US)Brazil (BR)Canada (CA)Ecuador (EC)Germany (DE)Netherlands (NL)Nigeria (NG)South Africa (ZA)Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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