Cinacalcet

Chemical formula: C₂₂H₂₂F₃N  Molecular mass: 357.412 g/mol  PubChem compound: 156419

Therapeutic indications

Cinacalcet is indicated for:

Secondary hyperparathyroidism (HPT) in adult patients with end-stage renal disease (ESRD)

Population group: only adults (18 years old or older)

Cinacalcet is indicated for the treatment of secondary hyperparathyroidism (HPT) in adult patients with end-stage renal disease (ESRD) on maintenance dialysis therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Secondary hyperparathyroidism (HPT) in children with end-stage renal disease (ESRD)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of secondary hyperparathyroidism (HPT) in children aged 3 years and older with end-stage renal disease (ESRD) on maintenance dialysis therapy in whom secondary HPT is not adequately controlled with standard of care therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Parathyroid carcinoma and primary hyperparathyroidism

Population group: only adults (18 years old or older)

Reduction of hypercalcaemia in adult patients with:

  • Parathyroid carcinoma.
  • Primary HPT for whom parathyroidectomy would be indicated on the basis of serum calcium levels (as defined by relevant treatment guidelines), but in whom parathyroidectomy is not clinically appropriate or is contraindicated.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Cinacalcet is contraindicated in the following cases:

Hypocalcaemia

Hypocalcemia

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