Chemical formula: C₂₀H₂₉N₃O₂ Molecular mass: 343.463 g/mol PubChem compound: 3025
Cinchocaine is a local anaesthetic agent and is suitable for surface or spinal anaesthesia and for relaxing sphincteric spasms. It is an anaesthetic of the amide type. It is more toxic than cocaine by local application but its local anaesthetic action is greater so it can be used in lower concentrations. Its action is more prolonged than lignocaine.
Surface or topical anaesthetics such as cinchocaine block the sensory nerve endings in the skin preventing transmissions of impulses along the nerve fibres and inhibiting depolarisation and ion-exchange. These effects are reversible. Before this blocking action can occur the lipid soluble anaesthetic base must penetrate the lipoprotein nerve sheath and the effectiveness of the anaesthetic depends on the concentration attained in the nerve fibre. The onset of action varies depending on the anaesthetic used. Cinchocaine has a rapid onset of action and is also long lasting.
Most local anaesthetics such as cinchocaine are absorbed through damaged skin. Cinchocaine is an ester-type local anaesthetic. Following absorption it is hydrolysed by esterases in the plasma and liver.
Not applicable.
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