Colchicine

Chemical formula: C₂₂H₂₅NO₆  Molecular mass: 399.443 g/mol  PubChem compound: 2833

Therapeutic indications

Colchicine is indicated for:

Acute gout

Population group: only adults (18 years old or older)

Treatment of acute gout.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of gout attack during initiation of therapy with allopurinol and uricosuric drugs

Population group: only adults (18 years old or older)

Preventive procedure and additionally Primary gout

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of familial Mediterranean fever

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Preventive procedure and additionally Periodic disease

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of amyloidosis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Preventive procedure and additionally Amyloidosis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Colchicine is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Blood dyscrasias

Blood disease

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe hepatic impairment

Hepatic failure stage IV

Renal or hepatic impairment and P-glycoprotein (P-gp) inhibitor or a strong CYP3A4 inhibitor

at least one of
Renal failure
Hepatic insufficiency
and additionally at least one of
P-glycoprotein inhibitors
Strong CYP3A4 inhibitors

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2022: COLCHICINE Tablet
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