Crizotinib

Chemical formula: C₂₁H₂₂Cl₂FN₅O  Molecular mass: 450.337 g/mol  PubChem compound: 11626560

Therapeutic indications

Crizotinib is indicated for:

First-line treatment of ALK-positive non-small cell lung cancer

Population group: only adults (18 years old or older)

Crizotinib as monotherapy is indicated for the first-line treatment of adults with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

ROS1-positive advanced non-small cell lung cancer (NSCLC)

Population group: only adults (18 years old or older)

Crizotinib as monotherapy is indicated for the treatment of adults with ROS1-positive advanced non-small cell lung cancer (NSCLC).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Second-line treatment of ALK-positive non-small cell lung cancer

Population group: only adults (18 years old or older)

Crizotinib as monotherapy is indicated for the treatment of adults with previously treated anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Crizotinib as monotherapy is indicated for the treatment of paediatric patients (age ≥1 to <18 years) with relapsed or refractory systemic anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Anaplastic lymphoma kinase (ALK)-positive inflammatory myofibroblastic tumour

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Crizotinib as monotherapy is indicated for the treatment of paediatric patients (age ≥1 to <18 years) with recurrent or refractory anaplastic lymphoma kinase (ALK)-positive unresectable inflammatory myofibroblastic tumour (IMT).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

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