Chemical formula: C₁₈H₂₂N₂ Molecular mass: 266.381 g/mol PubChem compound: 6726
Cyclizine interacts in the following cases:
Cyclizine may have additive effects with alcohol and other central nervous system depressants e.g. hypnotics, tranquillisers, anaesthetics, antipsychotics, barbiturates.
Cyclizine should be used with caution in patients with severe heart failure or acute myocardial infarction. In such patients, cyclizine may cause a fall in cardiac output associated with increases in heart rate, mean arterial pressure and pulmonary wedge pressure.
Cyclizine may mask the warning signs of damage caused by ototoxic drugs such as aminoglycoside antibacterials.
Cyclizine may counteract the haemodynamic benefits of opioid analgesics.
Because of its anticholinergic activity cyclizine may enhance the side-effects of other anticholinergic drugs, and have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs).
Cyclizine enhances the soporific effect of pethidine.
As with other anticholinergic agents, cyclizine may precipitate incipient glaucoma and it should be used with caution and appropriate monitoring in patients with glaucoma, urinary retention, obstructive disease of the gastrointestinal tract, hepatic disease, phaeochromocytoma, hypertension, epilepsy and in males with possible prostatic hypertrophy.
Cyclizine should be avoided in porphyria.
In the absence of any definitive human data, the use of cyclizine in pregnancy is not advised.
Cyclizine is excreted in human milk, however, the amount has not been quantified.
In a study involving prolonged administration of cyclizine to male and female rats, there was no evidence of impaired fertility after continuous treatment for 90-100 days at dose levels of approximately 15 and 25 mg/kg/day. There is no experience of the effect of cyclizine on human fertility.
Studies designed to detect drowsiness did not reveal sedation in healthy adults who took a single oral therapeutic dose (50 mg) of cyclizine. Patients should not drive or operate machinery until they have determined their own response. Although there are no data available, patients should be cautioned that cyclizine may have additive effects with alcohol and other central nervous system depressants, e.g. hypnotics and tranquillisers.
Adverse reactions are ranked under heading of frequency, the most frequent first, using the following convention: Very common: (≥1/10); Common (≥1/100 to <1/10); Uncommon (≥1/1,000 to <1/100); Rare (≥1/10,000 to <1/1,000); Very rare (<1/10,000); Not known: cannot be estimated from the available data.
Not known: Agranulocytosis, leucopenia, haemolytic anaemia, thrombocytopenia
Not known: Tachycardia, palpitations, arrhythmias
Not known: Tinnitus
Not known: Blurred vision, oculogyric crisis
Not known: Dryness of the mouth, nose and throat, constipation increased gastric reflux. Nausea, vomiting, diarrhoea stomach pain. Loss of appetite
Not known: Asthenia
Not known: Hepatic dysfunction including hepatitis due to hypersensitivity.
Cholestatic jaundice and cholestatic hepatitis have occurred in association with cyclizine.
Not known: Hypersensitivity reactions, including anaphylaxis have occurred
Not known: Twitching, muscle spasms
Not known: Effects on the central nervous system have been reported with cyclizine these include somnolence, drowsiness, incoordination headache, dystonia, dyskinesia, extrapyramidal motor disturbances, tremor, convulsions, dizziness, decreased consciousness, transient speech disorders, paraesthesia and generalised chorea*
Not known: Disorientation, restlessness, nervousness, euphoria, insomnia and auditory and visual hallucinations have been reported, particularly when dosage recommendations have been exceeded
Not known: Urinary retention
Not known: Bronchospasm, apnoea
Not known: Urticaria, drug rash, angioedema, allergic skin reactions, fixed drug eruption photosensitivity
Not known: Hypertension, hypotension
* There have been rare case reports of patients experiencing depressed levels of consciousness/loss of consciousness. The use of cyclizine has been associated with cases of paralysis following administration of the intravenous formulation of the medicine. The onset of paralysis is usually within minutes of administration, affects the limbs, and fully resolves within hours of discontinuation of the medicine.
IV formulation only:
Blisters at the site of injection and pruritus, as well as sensation of heaviness, chills, agitation, flushing and hypotension have been reported.
Rapid IV administration can lead to symptoms similar to overdose.
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