Cyclophosphamide Other names: Cytophosphane

Chemical formula: C₇H₁₅Cl₂N₂O₂P  Molecular mass: 261.086 g/mol  PubChem compound: 2907

Therapeutic indications

Cyclophosphamide is indicated for:

Acute Lymphocytic Leukemia (ALL)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Acute lymphoid leukemia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Hodgkin's lymphoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Hodgkin's disease (clinical)

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Non-Hodgkin's lymphoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Non-Hodgkin's lymphoma (clinical)

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Multiple Myeloma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Multiple myeloma (clinical)

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Metastatic ovarian carcinoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

† Ovarian cancer, disseminated

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Metastatic breast carcinoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

† Metastasis from malignant tumor of breast

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Ewing's sarcoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Ewing's sarcoma of bone

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Small cell lung cancer

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Small cell carcinoma of lung

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Advanced or metastatic neuroblastoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Neuroblastoma

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Severe progressive forms of lupus nephritis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

SLE glomerulonephritis syndrome

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Wegener's granulomatosis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Necrotising respiratory granulomatosis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Bone marrow transplantation and Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, Acute Myelogenous Leukemia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

As conditioning for a bone marrow transplantation, in the treatment of Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia and Acute Myelogenous Leukemia, in combination with whole body irradiation or busulfan.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Cyclophosphamide is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Urinary outflow obstruction

Urinary outflow obstruction

Urinary tract infection

Urinary tract infectious disease

Bone marrow aplasia, bone marrow depression

at least one of
Bone marrow granulocytic aplasia
Bone marrow depression

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