Dacarbazine

Chemical formula: C₆H₁₀N₆O  Molecular mass: 182.187 g/mol  PubChem compound: 5351166

Therapeutic indications

Dacarbazine is indicated for:

Malignant melanoma

Population group: only adults (18 years old or older)

Malignant melanoma

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Hodgkin's disease

Population group: only adults (18 years old or older)

Hodgkin's disease (clinical)

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Soft tissue sarcoma

Population group: only adults (18 - 65 years old)

Sarcoma of soft tissue

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Dacarbazine is contraindicated in the following cases:

Hypersensitivity to dacarbazine

Dacarbazine allergy

Pregnancy

Pregnancy

Lactation

Lactation

Leukopenia, thrombocytopenia

at least one of
Leukopenia
Decreased blood leukocyte number
Thrombocytopenic disorder

Severe liver diseases

Hepatic failure stage IV

Severe kidney diseases

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2017: DACARBAZINE Powder for solution for injection or infusion
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