Chemical formula: C₁₄H₁₀N₄O₅ Molecular mass: 314.257 g/mol PubChem compound: 6914273
The receptor molecule for dantrolene has not been identified. Dantrolene inhibits the binding of ryanodine. Under some conditions, dantrolene will lower intra-sarcoplasmic calcium concentrations in the resting state. This may be more important in diseased muscle (e.g. In malignant hyperthermia in humans and swine stress syndrome) than in muscle with normal function.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| M03CA01 | Dantrolene | M Musculo-skeletal system → M03 Muscle relaxants → M03C Muscle relaxants, directly acting agents → M03CA Dantrolene and derivatives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| DANTRIUM Capsules | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| DANTRIUM Powder for solution for injection | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Dantrolene is an active ingredient of these brands:
United States (US)Australia (AU)
Canada (CA)
Estonia (EE)
France (FR)
Ireland (IE)
Japan (JP)
Malta (MT)
Netherlands (NL)
New Zealand (NZ)
Romania (RO)
South Africa (ZA)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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