Chemical formula: C₂₀H₂₄N₂ Molecular mass: 292.418 g/mol PubChem compound: 21855
Dimetindene interacts in the following cases:
The anticholinergic activity of dimetindene is increased by MAO inhibitors, tricyclic antidepressants and anticholinergics.
The repressive action of dimetindene is increased by the simultaneous intake of alcohol or other CNS depressants.
Dimetindene increases the activity of epinephrine.
Caution is advised when bimetaline is administered to patients with chronic obstructive pulmonary disease.
Dimetindene should be avoided at hyperthyroidism.
Dimetindene should be avoided at increased intraocular pressure.
Dimetindene should be avoided at systemic arterial hypertension.
Dimetindene should be avoided at cardiovascular disorder.
Safety during pregnancy is not assured. Studies with oral taken dimethindene in animals have shown no teratogenic effects or other adverse effects in the fetus. Dimethidine should be used during pregnancy only when treatment is necessary and the expected benefit compensates for possible embryo dangers.
A study performed in animals has shown that very small amounts of dimethindene and/or of its metabolites are secreted in the mother’s milk. The use of dimethindene is not recommended during breast-feeding.
The administration of dimethindene can impair wakefulness; for concerned patients, caution is recommended in case of car driving or tasks requiring alertness (such as for instance the operation of machines).
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