Diphenhydramine

Chemical formula: C₁₇H₂₁NO Molecular mass: 255.355 g/mol PubChem compound: 3100

Therapeutic indications

Diphenhydramine is indicated for:

Sleep disturbance

Population group: only adults (18 years old or older)

Diphenhydramine is indicated as a symptomatic aid to the relief of temporary sleep disturbance in adults.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50 mg 20 min before going to bed for 7 days

Non-productive cough

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

In the symptomatic relief of non-productive cough.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

14 mg or 28 mg 3 to 4 times daily

Allergic conditions and reactions

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

In the symptomatic relief of allergic conditions and reactions.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

14 mg or 28 mg 3 to 4 times daily

Motion sickness

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Motion sickness

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50 mg 30 min before exposure to motion and similar doses before meals and upon retiring for the duration of exposure

25 mg 30 min before exposure to motion and similar doses before meals and upon retiring for the duration of exposure

Motion sickness

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Motion sickness

For this indication, competent medicine agencies globally authorize below treatments (click for details):

25-50 mg 3-4 times daily

12.5-25 mg 3-4 times daily

Parkinsonism

Population group: only adults (18 years old or older)

For parkinsonism (including drug-induced) in the elderly unable to tolerate more potent agents; mild cases of parkinsonism (including drug-induced) in other age groups; in other cases of parkinsonism (including drug-induced) in combination with centrally acting anticholinergic agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

25-50 mg 3-4 times daily

Contraindications

Diphenhydramine is contraindicated in the following cases:

Stenosing peptic ulcer

Peptic ulcer

Pyloroduodenal obstruction

Pyloric obstruction and additionally Obstruction of duodenum

Phaeochromocytoma

Phaeochromocytoma

QT interval prolongation

at least one of

Prolonged QT interval
Long QT syndrome

Patients with risk factors for QT prolongation, QT prolonging medicinal products

at least one of

Drugs prolonging QT interval
Risk factors that increase the risk of QT prolongation

Monoamine oxidase inhibitors

Monoamine oxidase inhibitors (MAOIs)

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