Domperidone

Chemical formula: C₂₂H₂₄ClN₅O₂  Molecular mass: 425.911 g/mol  PubChem compound: 3151

Therapeutic indications

Domperidone is indicated for:

Nausea and vomiting

Population group: only children (1 year - 12 years old)

Domperidone is indicated for the relief of the symptoms of nausea and vomiting.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Nausea and vomiting

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Domperidone is indicated for the relief of the symptoms of nausea and vomiting.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Domperidone is contraindicated in the following cases:

Moderate or severe hepatic impairment

at least one of
Hepatic failure stage III
Hepatic failure stage IV

Prolactin-releasing pituitary tumour (prolactinoma)

Prolactinoma

Gastro-intestinal haemorrhage

Gastro-intestinal mechanical obstruction

Gastro-intestinal perforation

Prolonged QT interval

at least one of
Prolonged QT interval
Long QT syndrome
Risk factors that increase the risk of QT prolongation

QT-prolonging drugs

Drugs prolonging QT interval

Potent CYP3A4 inhibitors

Strong CYP3A4 inhibitors

Concomitant use of the following substances with domperidone is contraindicated

at least one of
Disopyramide
Hydroquinidine
Quinidine
Amiodarone
Dofetilide
Dronedarone
Ibutilide
Sotalol
Haloperidol
Pimozide
Sertindole
Citalopram
Escitalopram
Erythromycin
Levofloxacin
Moxifloxacin
Spiramycin
Pentamidine
Halofantrine
Lumefantrine
Cisapride
Dolasetron
Prucalopride
Mequitazine
Mizolastine
Toremifene
Vandetanib
Vincamine
Bepridil
Diphemanil
Methadone
Clarithromycin
Telithromycin
Protease inhibitors
Triazole and tetrazole derivatives

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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