Duloxetine

Chemical formula: C₁₈H₁₉NOS  Molecular mass: 297.415 g/mol  PubChem compound: 60835

Therapeutic indications

Duloxetine is indicated for:

Moderate to severe Stress Urinary Incontinence (SUI)

Population group: only adults (18 years old or older)

Duloxetine is indicated for women for the treatment of moderate to severe Stress Urinary Incontinence (SUI).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Major depressive disorder

Population group: only adults (18 years old or older)

Major depressive disorder

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Generalised anxiety disorder

Population group: only adults (18 years old or older)

Generalized anxiety disorder

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Diabetic peripheral neuropathic pain

Population group: only adults (18 years old or older)

Diabetic peripheral neuropathy

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Duloxetine is contraindicated in the following cases:

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Hepatic impairment

Hepatic insufficiency

Νonselective irreversible monoamine oxidase inhibitors

Non selective Monoamine Oxidase Inhibitors and additionally not Reversible inhibitors of monoamine oxidase A (RIMAs)

CYP1A2 inhibitors

Inhibitors Cytochrome P450 1A2

Uncontrolled hypertension

Hypertension

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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