Eplerenone

Chemical formula: C₂₄H₃₀O₆  Molecular mass: 414.491 g/mol  PubChem compound: 443872

Therapeutic indications

Eplerenone is indicated for:

Left ventricular dysfunction (LVEF ≤40%)

Population group: only adults (18 years old or older)

Eplerenone is indicated in addition to standard therapy including beta-blockers, to reduce the risk of cardiovascular (CV) mortality and morbidity in stable patients with left ventricular dysfunction (LVEF ≤40%) and clinical evidence of heart failure after recent myocardial infarction (MI).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

NYHA class II (chronic) heart failure

Eplerenone is indicated in addition to standard optimal therapy, to reduce the risk of CV mortality and morbidity in adult patients with New York Heart Association (NYHA) class II (chronic) heart failure and left ventricular systolic dysfunction (LVEF ≤30%).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Eplerenone is contraindicated in the following cases:

Hyperkalemia

at least one of
Raised serum potassium level
Hyperkalemia

Severe renal insufficiency

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe hepatic insufficiency

at least one of
Hepatic failure stage III
Hepatic failure stage IV

Potassium-sparing diuretics, potassium supplements

at least one of
Potassium-sparing agents
Potassium

Strong inhibitors of CYP3A4

Strong CYP3A4 inhibitors

Angiotensin converting enzyme (ACE) inhibitor

ACE inhibitors, plain

Angiotensin receptor blocker (ARB)

Angiotensin II antagonists, plain

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