Eptifibatide

Chemical formula: C₃₅H₄₉N₁₁O₉S₂  Molecular mass: 831.316 g/mol 

Therapeutic indications

Eptifibatide is indicated for:

Unstable angina, non-Q-wave myocardial infarction

Population group: only adults (18 years old or older)

Eptifibatide is indicated for the prevention of early myocardial infarction in adults presenting with unstable angina or non-Q-wave myocardial infarction, with the last episode of chest pain occurring within 24 hours and with electrocardiogram (ECG) changes and/or elevated cardiac enzymes.

Patients most likely to benefit from eptifibatide treatment are those at high risk of developing myocardial infarction within the first 3-4 days after onset of acute angina symptoms including for instance those that are likely to undergo an early PTCA (Percutaneous Transluminal Coronary Angioplasty).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Eptifibatide is contraindicated in the following cases:

Stroke, haemorrhagic stroke

at least one of
CVA - Cerebrovascular accident
Intracranial hemorrhage

Glycoprotein (GP) IIb/IIIa inhibitors

Glycoprotein IIb/IIIa inhibitors

Significant hepatic impairment

Hepatic failure stage IV

Severe renal impairment (creatinine clearance <30 ml/min), renal dialysis

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)
Renal dialysis

Severe hypertension

Hypertensive crisis

Prothrombin time >1.2 times control, International Normalized Ratio (INR) ≥2.0

at least one of
Prothrombin time increased
International normalized ratio above reference range

Thrombocytopenia (<100,000 cells/mm³)

Thrombocytopenic disorder

Bleeding diathesis

Blood coagulation disorder

Gastrointestinal bleeding, genitourinary bleeding, abnormal bleeding

at least one of
Gastrointestinal hemorrhage
Bleeding

Intracranial neoplasm, arteriovenous malformation, aneurysm

at least one of
Intracranial tumour
Intracranial vascular malformation
Cerebral aneurysm

Major surgery, severe trauma

at least one of
H/O: major vascular surgery
H/O: major abdominal surgery
History of major orthopedic surgery
History of cardiovascular surgery
Traumatic injury

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