Chemical formula: C₂₂H₂₃N₃O₄ Molecular mass: 393.436 g/mol PubChem compound: 176870
Erlotinib is indicated for:
Population group: only adults (18 years old or older)
Erlotinib is indicated for the first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR activating mutations.
Erlotinib is also indicated for switch maintenance treatment in patients with locally advanced or metastatic NSCLC with EGFR activating mutations and stable disease after first-line chemotherapy.
Erlotinib is also indicated for the treatment of patients with locally advanced or metastatic NSCLC after failure of at least one prior chemotherapy regimen. In patients with tumours without EGFR activating mutations, erlotinib is indicated when other treatment options are not considered suitable.
When prescribing erlotinib, factors associated with prolonged survival should be taken into account.
No survival benefit or other clinically relevant effects of the treatment have been demonstrated in patients with Epidermal Growth Factor Receptor (EGFR)-IHC negative tumours.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Population group: only adults (18 years old or older)
Erlotinib in combination with gemcitabine is indicated for the treatment of patients with metastatic pancreatic cancer.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
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