Chemical formula: C₂₆H₂₅N₃O₃S Molecular mass: 459.56 g/mol PubChem compound: 72098
The use of fenoverine is not recommended during pregnancy, as its effects have not been fully established.
Administration of fenoverine during breast-feeding is not recommended as the possible excretion into the mother’s milk has not been determined.
Fenoverine is not known to influence driving and the use of machines.
The most common side effects observed are:
The above-mentioned side effects resolved in 24-48 hours, without terminating the treatment.
Rare side effects are:
Individual events of myalgias and of reversible rhabdomyolysis were reported, particularly in elderly patients under multiple drug treatment. Rhabdomyolysis is often associated with renal insufficiency. Rhabdomyolysis is a potential adverse event of many therapeutic classes, and commonly seen with cholesterol-lowering agents. It is also known, however, to be genetically determined in subjects with inherited predisposition to malignant hyperthermia, and in subjects with inherited predisposition to myoglobinuria. All monitored events occurred in elderly patients (>65 years), and/or in patients with severely impaired liver function (liver cancer, terminal cirrhosis). All were under multiple treatments, and in almost all cases given a very high dose of fenoverine. These are conditions known to facilitate the occurrence of any kind of adverse events, including rhabdomyolysis. When the contraindications specified are followed (avoid administration to the elderly; in cases of liver insufficiency such as those due to hepatitis, cirrhosis, addiction to alcohol or narcotics; concomitantly with drugs that overload the metabolic capacity of the liver; to patients with renal failure) the risk is dramatically decreased. When these precautions have been followed, no events of rhabdomyolysis have been reported.
If side effects occur, the physician should carefully consider whether or not to discontinue treatment.
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