Fenspiride

Chemical formula: C₁₅H₂₀N₂O₂  Molecular mass: 260.332 g/mol  PubChem compound: 3344

Pharmacodynamic properties

Fenspiride has an anti-inflammatory and bronchodilator activity. These properties are most likely due to several concomitant mechanisms of action, such as:

  • antagonistic effect on histamine H1 receptors and papaverine like spasmolytic effect (or musculo tropic);
  • anti-inflammatory effect which may result from the reduced secretion of inflammatory mediators (cytokines, TNF-α, arachidonic acid derivatives, free radicals).

Pharmacokinetic properties

The plasma peak concentration after oral administration of fenspiride is reached within an average of 2.3 ± 2.5 hours. The half-life is approximately 12 hours. Fenspiride is primarily eliminated via kidneys.

Preclinical safety data

There are no adequate non-clinical data on the safety of fenspiride.

< Previous: Precautions

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.

⇈