Human fibrinogen

Active ingredient description

Human fibrinogen (coagulation factor I), in the presence of thrombin, activated coagulation factor XIII (F XIIIa) and calcium ions is converted into a stable and elastic three-dimensional fibrin haemostatic clot. The administration of human fibrinogen concentrate provides an increase in plasma fibrinogen level and can temporarily correct the coagulation defect of patients with fibrinogen deficiency.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code	Group title	Classification
B02BB01	Human fibrinogen	B Blood and blood forming organs → B02 Antihemorrhagics → B02B Vitamin K and other hemostatics → B02BB Fibrinogen
Discover more medicines within B02BB01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title	Information Source	Document Type
RIASTAP Powder for solution for injection or infusion	Medicines & Healthcare Products Regulatory Agency (GB)	MPI, EU: SmPC

Medicines

Human fibrinogen is an active ingredient of these brands:

United States (US)

RIASTAP as Human fibrinogen
(combination) ARTISS FIBRIN SEALANT
(combination) EVARREST
(combination) TACHOSIL
(combination) TISSEEL

Austria (AT)

FIBCLOT
FIBRYGA
HAEMOCOMPLETTAN
(combination) ARTISS
(combination) EVICEL as Human clottable protein
(combination) TACHOSIL
(combination) TISSEEL
(combination) VERASEAL

Brazil (BR)

FIBRYGA
HAEMOCOMPLETTAN
(combination) BERIPLAST-P as Human plasma protein fraction (Fibrinogen)
(combination) EVICEL as Human clottable protein
(combination) TACHOSIL
(combination) TISSEEL

Canada (CA)

FIBRYGA
RIASTAP as Human fibrinogen
(combination) ARTISS
(combination) EVICEL as Human clottable protein
(combination) TISSEEL

Croatia (HR)

FIBRYGA
(combination) EVICEL as Human clottable protein
(combination) TACHOSIL
(combination) TISSEEL
(combination) VERASEAL

Cyprus (CY)

RIASTAP as Human fibrinogen

Ecuador (EC)

FIBRYGA
(combination) TISSEEL

Estonia (EE)

FIBRYGA
HAEMOCOMPLETTAN
(combination) EVARREST
(combination) EVICEL as Human clottable protein
(combination) RAPLIXA
(combination) TACHOSIL
(combination) TISSEEL
(combination) VERASEAL

Finland (FI)

FIBCLOT
FIBRYGA
RIASTAP as Human fibrinogen
(combination) ARTISS
(combination) EVICEL as Human clottable protein
(combination) TACHOSIL
(combination) TISSEEL
(combination) VERASEAL

France (FR)

CLOTTAFACT
FIBRYGA
RIASTAP as Human fibrinogen
(combination) ARTISS
(combination) EVICEL as Human clottable protein
(combination) TACHOSIL
(combination) TISSEEL
(combination) VERASEAL

Hong Kong (HK)

(combination) ARTISS
(combination) BERIPLAST-P as Human plasma protein fraction (Fibrinogen)
(combination) TACHOCOMB
(combination) TACHOSIL
(combination) TISSEEL

Ireland (IE)

FIBRYGA
RIASTAP as Human fibrinogen
(combination) ARTISS
(combination) EVICEL as Human clottable protein
(combination) TACHOSIL
(combination) TISSEEL
(combination) VERASEAL

Israel (IL)

(combination) TACHOSIL
(combination) TISSEEL

Italy (IT)

(combination) TACHOSIL
(combination) VERASEAL

Japan (JP)

(combination) BERIPLAST-P as Human plasma protein fraction (Fibrinogen)
(combination) TACHOSIL

Lithuania (LT)

FIBRYGA
(combination) EVARREST
(combination) EVICEL as Human clottable protein
(combination) RAPLIXA
(combination) TACHOSIL
(combination) VERASEAL

Malta (MT)

FIBRYGA
RIASTAP as Human fibrinogen
(combination) TISSEEL

Netherlands (NL)

HAEMOCOMPLETTAN

New Zealand (NZ)

RIASTAP as Human fibrinogen
(combination) TISSEEL

Poland (PL)

FIBRYGA
RIASTAP as Human fibrinogen
(combination) EVICEL as Human clottable protein
(combination) TACHOSIL
(combination) TISSEEL
(combination) VERASEAL

Romania (RO)

Singapore (SG)

FIBRYGA
(combination) ARTISS
(combination) EVICEL as Human clottable protein
(combination) TACHOSIL
(combination) TISSEEL

South Africa (ZA)

(combination) TACHOSIL

Spain (ES)

FIBCLOT
FIBRYGA
RIASTAP as Human fibrinogen
(combination) ARTISS
(combination) TACHOSIL
(combination) TISSEEL

Tunisia (TN)

HAEMOCOMPLETTAN

Turkey (TR)

HAEMOCOMPLETTAN
(combination) ARTISS
(combination) BERIPLAST-P as Human plasma protein fraction (Fibrinogen)
(combination) TACHOSIL
(combination) TISSEEL

United Kingdom (UK)

FIBCLOT
FIBRYGA
RIASTAP as Human fibrinogen
(combination) ARTISS
(combination) EVICEL as Human clottable protein
(combination) TACHOSIL
(combination) TISSEEL
(combination) VERASEAL

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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