Filgrastim Other names: r-metHuG-CSF

Therapeutic indications

Filgrastim is indicated for:

Neutropenia by cytotoxic chemotherapy for malignancy

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Filgrastim is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. The safety and efficacy of filgrastim are similar in adults and children receiving cytotoxic chemotherapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Mobilisation of peripheral blood progenitor cells (PBPCs)

Population group: only adults (18 - 65 years old)

Filgrastim is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Cyclic neutropenia, idiopathic neutropenia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

In patients, children or adults with cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤0.5 × 109/L, and a history of severe or recurrent infections, long term administration of filgrastim is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Congenital neutropenia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

In patients, children or adults with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤0.5 × 109/L, and a history of severe or recurrent infections, long term administration of filgrastim is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Persistent neutropenia in advanced HIV infection

Population group: only adults (18 - 65 years old)

Filgrastim is indicated for the treatment of persistent neutropenia (ANC less than or equal to 1.0 × 109/L) in patients with advanced HIV infection, in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Filgrastim is contraindicated in the following cases:

Hypersensitivity to filgrastim

Filgrastim allergy

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.