Fingolimod

Chemical formula: C₁₉H₃₃NO₂  Molecular mass: 307.471 g/mol  PubChem compound: 107970

Active ingredient description

Fingolimod is a sphingosine 1-phosphate receptor modulator. Fingolimod is metabolised by sphingosine kinase to the active metabolite fingolimod phosphate. By acting as a functional antagonist of S1P receptors on lymphocytes, fingolimod phosphate blocks the capacity of lymphocytes to egress from lymph nodes, causing a redistribution, rather than depletion, of lymphocytes.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L04AE01 Fingolimod L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AE Sphingosine-1-phosphate (S1P) receptor modulators
Discover more medicines within L04AE01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
GILENYA Hard capsule European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 162359-55-9
CAS Substance: 162359-56-0
DrugBank Drug: DB08868
KEGG Drug: D10001
PubChem Compound: 107970
RxNorm Ingredient: 1012892
SNOMED-CT Concept: 449000008
Fingolimod (substance)
UNII Identifier: 3QN8BYN5QF
FINGOLIMOD

Medicines

Fingolimod is an active ingredient of these brands:

United States (US)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Albania (AL)

  • VINTOR as FINGOLIMOD HYDROCHLORIDE

Australia (AU)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Austria (AT)

Brazil (BR)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Canada (CA)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Croatia (HR)

  • ARLESIAS as FINGOLIMOD HYDROCHLORIDE
  • EFIGALO as FINGOLIMOD HYDROCHLORIDE
  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Cyprus (CY)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Ecuador (EC)

Estonia (EE)

  • CHANTICO as FINGOLIMOD HYDROCHLORIDE
  • EFIGALO as FINGOLIMOD HYDROCHLORIDE
  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Finland (FI)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE
  • INZOLFI as FINGOLIMOD HYDROCHLORIDE

France (FR)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Hong Kong (HK)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Ireland (IE)

Israel (IL)

  • FINOLIM as FINGOLIMOD HYDROCHLORIDE
  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Japan (JP)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE
  • IMUSERA as FINGOLIMOD HYDROCHLORIDE

Lithuania (LT)

  • CHANTICO as FINGOLIMOD HYDROCHLORIDE
  • EFIGALO as FINGOLIMOD HYDROCHLORIDE
  • GILENYA as FINGOLIMOD HYDROCHLORIDE
  • INZOLFI as FINGOLIMOD HYDROCHLORIDE

Mexico (MX)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Netherlands (NL)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

New Zealand (NZ)

  • FYNOD as FINGOLIMOD HYDROCHLORIDE
  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Poland (PL)

Romania (RO)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE
  • INZOLFI as FINGOLIMOD HYDROCHLORIDE

Singapore (SG)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

South Africa (ZA)

Spain (ES)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Tunisia (TN)

Turkey (TR)

  • FINDEL as FINGOLIMOD HYDROCHLORIDE
  • FINGOLITU as FINGOLIMOD HYDROCHLORIDE
  • FINGYA as FINGOLIMOD HYDROCHLORIDE
  • FINIMOD as FINGOLIMOD HYDROCHLORIDE
  • FONDOS as FINGOLIMOD HYDROCHLORIDE
  • GILOMID as FINGOLIMOD HYDROCHLORIDE
  • GLIMSAR as FINGOLIMOD HYDROCHLORIDE
  • IMODYA as FINGOLIMOD HYDROCHLORIDE
  • JUDEXA as FINGOLIMOD HYDROCHLORIDE
  • VINTOR as FINGOLIMOD HYDROCHLORIDE

United Kingdom (UK)

  • GILENYA as FINGOLIMOD HYDROCHLORIDE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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