Fluciclovine ¹⁸F Other names: FACBC

Chemical formula: C₅H₈FNO₂  Molecular mass: 132.125 g/mol  PubChem compound: 450601

Active ingredient description

Fluciclovine ¹⁸F is a synthetic amino acid which is transported across mammalian cell membranes by amino acid transporters such as LAT-1 and ASCT2. The activities of LAT-1 and ASCT2 are known to be upregulated in prostate cancer, providing a mechanism for the enhanced accumulation of fluciclovine ¹⁸F in prostate cancer. Fluciclovine ¹⁸F is indicated for Positron Emission Tomography (PET) imaging to detect recurrence of prostate cancer.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
V09IX12 V Various → V09 Diagnostic radiopharmaceuticals → V09I Tumour detection → V09IX Other diagnostic radiopharmaceuticals for tumour detection
Discover more medicines within V09IX12

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
AXUMIN Solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 222727-39-1
DrugBank Drug: DB13146
PubChem Compound: 450601
RxNorm Ingredient: 1796118
SNOMED-CT Concept: 457000009
Fluciclovine (18-F) (substance)
UNII Identifier: 38R1Q0L1ZE
FLUCICLOVINE F-18

Medicines

Fluciclovine ¹⁸F is an active ingredient of these brands:

United States (US)

Austria (AT)

Croatia (HR)

Estonia (EE)

France (FR)

Ireland (IE)

Japan (JP)

Lithuania (LT)

Poland (PL)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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