Flucytosine

Chemical formula: Câ‚„Hâ‚„FN₃O  Molecular mass: 129.093 g/mol  PubChem compound: 3366

Active ingredient description

Flucytosine is a fluorinated pyrimidine derivative. It is an antimycotic agent exerting fungistatic and fungicidal activity by interfering with protein and DNA synthesis. Fluorodeoxyuridine interferes with the enzyme thymidylate synthase. Inhibition of thymidylate synthase subsequently causes disruption of DNA synthesis.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D01AE21 Flucytosine D Dermatologicals → D01 Antifungals for dermatological use → D01A Antifungals for topical use → D01AE Other antifungals for topical use
Discover more medicines within D01AE21
J02AX01 Flucytosine J Antiinfectives for systemic use → J02 Antimycotics for systemic use → J02A Antimycotics for systemic use → J02AX Other antimycotics for systemic use
Discover more medicines within J02AX01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ANCOTIL Solution for infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 2022-85-7
DrugBank Drug: DB01099
KEGG Drug: D00323
PubChem Compound: 3366
RxNorm Ingredient: 4451
SNOMED-CT Concept: 387155003
Flucytosine (substance)
UNII Identifier: D83282DT06
FLUCYTOSINE

Medicines

Flucytosine is an active ingredient of these brands:

United States (US)

Austria (AT)

Estonia (EE)

France (FR)

Ireland (IE)

Japan (JP)

Malta (MT)

Netherlands (NL)

Poland (PL)

South Africa (ZA)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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