Chemical formula: C₂₆H₃₂F₂O₇ Molecular mass: 494.525 g/mol PubChem compound: 9642
Fluocinonide is a synthetic anti-inflammatory corticosteroid. Its mechanisms of action are related to vasoconstriction and suppression of membrane permeability, mitotic activity, the immune response and release of inflammatory mediators.
The extent of percutaneous absorption of fluocinonide is determined by many factors including the vehicle, the integrity of the epidermal barrier and the use of occlusive dressings. Following absorption, fluocinonide is metabolised primarily in the liver and excreted by the kidneys.
Fluocinonide is a drug on which extensive clinical experience has been obtained.
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