Chemical formula: C₄H₆N₂ Molecular mass: 82.104 g/mol PubChem compound: 3406
Fomepizole is a competitive inhibitor of alcohol dehydrogenase. Alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde and the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. Fomepizole is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning (such as windshield washer fluid), or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| V03AB34 | Fomepizole | V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ANTIZOL Solution for injection | Health Products and Food Branch (CA) | MPI, CA: SPM |
Fomepizole is an active ingredient of these brands:
Canada (CA)New Zealand (NZ)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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