Fosinopril

Chemical formula: C₃₀H₄₆NO₇P  Molecular mass: 563.672 g/mol  PubChem compound: 55891

Therapeutic indications

Fosinopril is indicated for:

Hypertension

Population group: only adults (18 years old or older)

Fosinopril is indicated in the treatment of hypertension. Fosinopril may be used alone as initial therapy or in combination with other antihypertensive agents. The antihypertensive effects of Fosinopril and diuretics used concomitantly are approximately additive.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Heart failure

Population group: only adults (18 years old or older)

Fosinopril is indicated for the treatment of heart failure in combination with a non-potassium sparing diuretic and where appropriate, digitalis. In these patients, fosinopril improve symptoms and exercise tolerance, reduce severity of heart failure and decrease the frequency of hospitalisation for heart failure.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Fosinopril is contraindicated in the following cases:

Renal artery stenosis

RAS - Renal artery stenosis

Pregnancy

Pregnancy

Hypersensitivity to fosinopril

Fosinopril pseudoallergy

Hypersensitivity to other angiotencin-converting enzyme (ACE) inhibitors

Angiotensin-converting-enzyme inhibitor pseudoallergy

Angioneurotic oedema

Angioedema

Cardiogenic shock

Cardiogenic shock

Sacubitril, valsartan

at least one of
Sacubitril
Valsartan
Valsartan

Aliskiren in diabetes mellitus or renal impairment (GFR <60ml/min/1.73m²)

Aliskiren and additionally at least one of
Diabetes mellitus



Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

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